Selected Publications  

Original Research Articles

Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature. 2019; 569(7755):236-240. 

Eken SM, Christersdottir T, Winski G, Sangsuwan T, Jin H, Chernogubova E, Pirault J, Sun C, Simon N, Winter H, Backlund A, Haghdoost S, Hansson GK, Halle M, Maegdefessel L. miR-29b mediates the chronic inflammatory response in radiotherapy-induced vascular disease. JACC Basic Transl Sci. 2019; 4(1):72-82. 

Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdefessel L, Malin SG. Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability. Circulation. 2019; 139(21):2466-2482.

 

Khyzha N, Khor M, DiStefano PV, Wang L, Matic L, Hedin U, Wilson MD, Maegdefessel L, Fish JE. Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA. Proc Natl Acad Sci U S A. 2019; 116(33):16410-16419. 

Gomes CPDC, Ágg B, Andova A, Arslan S, Baker A, Barteková M, Beis D, Betsou F, Wettinger SB, Bugarski B, Condorelli G, Silva GJJD, Danilin S, de Gonzalo-Calvo D, Buil A, Carmo-Fonseca M, Enguita FJ, Felekkis K, Ferdinandy P, Gyöngyösi M, Hackl M, Karaduzovic-Hadziabdic K, Hellemans J, Heymans S, Hlavackova M, Hoydal MA, Jankovic A, Jusic A, Kardassis D, Kerkelä R, Kuster GM, Lakkisto P, Leszek P, Lustrek M, Maegdefessel L, Martelli F, Novella S, O'Brien T, Papaneophytou C, Pedrazzini T, Pinet F, Popescu O, Potočnjak I, Robinson E, Sasson S, Scholz M, Simionescu M, Stoll M, Varga ZV, Vinciguerra M, Xuereb A, Yilmaz MB, Emanueli C, Devaux On Behalf Of The Eu-CardioRNA Cost Action Ca Y. Catalyzing transcriptomics research in cardiovascular disease: The CardioRNA COST action CA17129. Noncoding RNA 2019; 29(5):2. 

Li DY, Busch A, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S, Lao S, Hofmann P, Bäcklund A, Eken SM, Roy J, Eriksson P, Dacken B, Ramanujam P, Dueck A, Engelhardt S, Boon RA, Eckstein HH, Spin JM, Tsao PS, Maegdefessel L. H19 induces abdominal aortic aneurysm development and progression. Circulation. 2018; 138(15):1551-1568.

Jin H, Li DY, Chernogubova E, Sun C, Busch A, Eken SM, Saliba-Gustafsson P, Winter H, Winski G, Raaz U, Schellinger IN, Simon N, Hegenloh R, Matic LP, Jagodic M, Ehrenborg E, Pelisek J, Eckstein HH, Hedin U, Backlund A, Maegdefessel L. Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions. Mol Ther. 201826(4):1040-1055. 

Kojima Y, Werner N, Ye J, Nanda V, Tsao N, Wang Y, Flores AM, Miller CL, Weissman I, Deng H, Xu B, Dalman RL, Eken SM, Pelisek J, Li Y, Maegdefessel L, Leeper NJ. Proefferocytotic Therapy Promotes Transforming Growth Factor beta Signaling and Prevents Aneurysm Formation. Circulation. 2018; 137(7):750-753.

 

Di Gennaro A, Araújo AC, Busch A, Jin H, Wågsäter D, Vorkapic E, Caidahl K, Eriksson P, Samuelsson B, Maegdefessel L, Haeggström JZ. Cysteinyl leukotriene receptor 1 antagonism prevents experimental aortic aneurysm. Proc Natl Acad Sci U S A. 2018; 115(8):1907-1912

 

Eken SM, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein HH, Pelisek J, Eriksson P, Gonzalez Diez M, Matic Perisic LP, Schellinger IN, Raaz U, Leeper NJ, Hansson GK, Paulsson-Berne G, Hedin U, Maegdefessel L. MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions. Circ Res. 2017; 120:633-44.

 

Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Hedin U, Weissman IL, Leeper NJ. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016; 536: 86-90.

 

Wang D, Deuse T, Stubbendorff M, Chernogubova E, Erben RG, Eken SM, Jin H, Li Y, Busch A, Heeger CH, Behnisch B, Reichenspurner H, Robbins RC, Spin JM, Tsao PS, Schrepfer S, Maegdefessel L. Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis. Arterioscler Thromb Vasc Biol. 2015; 35(9):1945-53. 

 

Maegdefessel L, Spin JM, Raaz U, Adam M, Azuma J, Toh RM, Deng A, Chernogubova E, Eken SM, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Mc Connell MV, Hamsten A, Eriksson P, Dalman RL, Tsao PS. miR-24 limits aortic vascular inflammation and murine abdominal aortic aneurysm development. Nat Commun. 2014; 5:5214.

Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolanos JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Langer F, Zeller T, Schulte-Uentrop L, Stöhr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. Nature. 2014; 509:641-44

 

Maegdefessel L, Azuma J, Toh RM, Merk DR, Deng A, Raiesdana A, Leeper NJ, Raaz, U, Schoelmerich A, Mc Connell MV, Dalman RL, Spin JM, Tsao PS. Induction of microRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med. 2012; 4:122ra22.

 

Maegdefessel L, Azuma J, Toh RM, Merk DR, Deng A, Chin JT, Raiesdana A, Leeper NJ, Raaz, U, Schoelmerich A, Mc Connell MV, Dalman RL, Spin JM, Tsao PS. Inhibition of microRNA-29b reduces abdominal aortic aneurysm development. J Clin Invest. 2012; 122:497-506.

 

Review Articles and Editorials

Knappich C, Spin JM, Eckstein HH, Tsao PS, Maegdefessel L. Involvement of Myeloid Cells and Non-Coding RNA in Abdominal Aortic Aneurysm Disease. Antioxid Redox Signal. 2020; Jan 28. doi: 10.1089/ars.2020.8035.

 

Wu ZY, Trenner M, Boon RA, Spin JM, Maegdefessel L. Long noncoding RNAs in key cellular processes involved in aortic aneurysms. Atherosclerosis. 2020; 292:112-118.

 

Eckstein HH, Maegdefessel L. Linking obesity with abdominal aortic aneurysm development. Eur Heart J. 2019; pii: ehz882. doi: 10.1093/eurheartj/ehz882.

 

Fasolo F, Di Gregoli K, Maegdefessel L, Johnson JL. Non-coding RNAs in cardiovascular cell biology and atherosclerosis. Cardiovasc Res. 2019; 115(12):1732-1756.

Paloschi V, Winter H, Viola J, Soehnlein O, Maegdefessel L. Mechanistic links between non-coding RNAs and myeloid cell inflammation in atherosclerosis. Thromb Haemost. 2019; 119(8):1205-1211

Kumar S, Boon RA, Maegdefessel L, Dimmeler S, Jo H. Role of non-coding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm: Possible Therapeutic Targets? Circ Res. 2019; 124(4):619-630.

Leeper NJ, Maegdefessel L. Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease. Cardiovasc Res. 2018; 114:611-621.

Paloschi V, Maegdefessel L. Towards Point-of-Care Measurements Using Noncoding RNAs: A Novel Tool to Monitor Aggravation of Advanced Atherosclerotic Lesions. Circ Cardiovasc Genet. 2017; pii: e001859.

 

Li Y, Maegdefessel L. Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression. Front Physiol. 2017; 8:429.

Busch A, Eken SM, Maegdefessel L. Prospective and therapeutic screening value of non-coding RNA as biomarkers in cardiovascular disease. Ann Transl Med. 2016; 4:236.

Full publication list available at: https://www.ncbi.nlm.nih.gov/pubmed/?term=maegdefessel

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